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Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4. This complex aike c099 the formation of clathrin-coated pits Foti et al.

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The structure shows that all of these residues are well ordered in the complex, in contrast aike c099 all previous structures of Nef—effector complexes. The work is made available under the Creative Commons CC0 public domain dedication. Mutational analyses have shown that this site is also required for Nef binding, most likely through recognition of the Nef dileucine motif Mattera et al. DahlAaikeNygaard ls Norsk Regnesentral.

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